We just got a new Beagle puppy. It has been about 10 years since I last had a dog (also a Beagle). When we took him for his first vet exam, the vet told us about Vectra 3D for flea & tick control. I thought I'd try it the next day. When the first drop touched my dog's skin, he screamed like he was being branded with a hot iron ! I couldn't see any redness or anything else at the spot. I thought maybe he thought he was getting another shot (he didn't like that at the vet the day before). I finished applying the Vectra in another spot after he calmed down. He didn't cry that time. I have not noticed anything bad with his skin since (2 days now)....no redness, no sensisitivity, no scratching. But that awful crying has me thinking I'll try Frontline Plus next month just in case. I am pretty sure it was Frontline we used years ago with our other dog. Has anybody else experienced anything similar to this with Vectra 3D....or Frontline Plus for that matter ?