My dog has been itching and chewing on herself terribly even while taking 1/2 antihistimine twice a day (for 6wks). I read about Skin-Eze and ordered a bottle, it came in today so I gave her the recommended dosage and she suddenly appeared to have lost control of her bladder. She is 5-6 months old and this is never happened before and she is very lethargic. I am obviously not going to give her anymore but I was wondering if anyone else has has used this product. I have emailed the company about my experience and hopefully they will get back to me ASAP.